maly_ludek_legoGruba ryba
7piorunów>
>
> Obecnie obawiamy się transmisji podczas pracy laboratoryjnej i operacji neurochirurgicznych. Chodzi zwłaszcza o narzędzia używane podczas operacji neurochirurgicznych, ponieważ tkanka nerwowa jest – jeśli chodzi o priony – najbardziej zakaźna.
> Zwykła sterylizacja – w tym autoklawowanie – nie niszczy prionów. Priony są niezwykle odporne – rozkładają się dopiero w temperaturze 1000 stopni C.
:exploding_head:
https://naukawpolsce.pl/aktualnosci/news%2C113506%2Cprof-sikorska-mechanizmy-choroby-alzheimera-czy-parkinsona-podobne-do
#nauka #ciekawostki

Chyba się komuś przecinek przesunął.
https://en.wikipedia.org/wiki/Prion
"The World Health Organization recommends any of the following three procedures for the sterilization of all heat-resistant surgical instruments to ensure that they are not contaminated with prions:
1. Immerse in 1N sodium hydroxide and place in a gravity-displacement autoclave at 121 °C for 30 minutes; clean; rinse in water; and then perform routine sterilization processes.
2. Immerse in 1N sodium hypochlorite (20,000 parts per million available chlorine) for 1 hour; transfer instruments to water; heat in a gravity-displacement autoclave at 121 °C for 1 hour; clean; and then perform routine sterilization processes.
3. Immerse in 1N sodium hydroxide or sodium hypochlorite (20,000 parts per million available chlorine) for 1 hour; remove and rinse in water, then transfer to an open pan and heat in a gravity-displacement (121 °C) or in a porous-load (134 °C) autoclave for 1 hour; clean; and then perform routine sterilization processes.[[94]](https://en.wikipedia.org/wiki/Prion#cite_note-94)
Heating at 134 °C (273 °F) for 18 minutes in a pressurized steam autoclave has been found to be somewhat effective in deactivating prions."
PrionA prion ( ) is a misfolded protein that induces folding problems in normal variants of the same protein, leading to cellular death. Prions are responsible for prion diseases, which are fatal and transmissible neurodegenerative diseases affecting animals, including humans. These proteins can misfold sporadically, due to genetic mutations, or through exposure to an already misfolded protein, leading to an abnormal three-dimensional structure that can propagate misfolding in other proteins. The term prion derives from "proteinaceous infectious particle". Unlike other infectious agents such as viruses, bacteria, and fungi, prions do not contain nucleic acids (DNA or RNA). Prions are primarily twisted isoforms of the major prion protein (PrP), a naturally occurring protein with an uncertain function. They are the hypothesized cause of various diseases, including scrapie in sheep, chronic wasting disease (CWD)...Wikipedia















